| 主权项 |
1. A compound of the formula I wherein R denotes isoquinolin-1-, -4-, -5- or -6-yl which is unsubstituted or mono- or disubstituted by R5; R1 denotes H or A′, R2 denotes H, A′ or —[C(R6)2]n—Ar, R3 denotes H, A, Hal, CN, —[C(R6)2]n—Ar, —[C(R6)2]n-Het, —[C(R6)2]n-Cyc, OR6 or N(R6)2, R5 denotes A, Hal, CN, —[C(R6)2]n—Ar, —[C(R6)2]n-Het, —[C(R6)2]n-Cyc, OCyc, OHet′, OR6, N(R6)2, SO2A, SO2Ar or ═O, R6 denotes H or A′, A denotes unbranched or branched alkyl having 1-6 C atoms, in which one or two CH2 groups may be replaced by O, N and/or S atoms and/or by —CH═CH— groups and/or, in addition, 1-7 H atoms may be replaced by F, A′ denotes unbranched or branched alkyl having 1-4 C atoms or Cyc, Cyc denotes cycloalkyl having 3, 4, 5, 6 or 7 C atoms, Ar denotes phenyl which is unsubstituted or mono-, di- or trisubstituted by Hal, A, —[C(R6)2]nOR6, N(R6)2, NO2, CN, COOR6, CON(R6)2, NR6COA, NR6SO2A, COR6, SO2N(R6)2 and/or S(O)nA, Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms which is unsubstituted or mono- or disubstituted by Hal, A, —[C(R6)2]nOR6, N(R6)2, NO2, CN, COOR6, CON(R6)2, NR6COA, NR6SO2A, COR6, SO2NR6 and/or S(O)nA, Het′ denotes a monocyclic saturated heterocycle having 1 or 2 N, O and/or S atoms which is unsubstituted or mono- or disubstituted by A and/or ═O, Hal denotes F, Cl, Br or I, n denotes 0, 1 or 2, and pharmaceutically usable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. |
