Intelligent Dynamic Range Enhancement

摘要

A method of mass spectrometry is disclosed comprising transmitting ions and obtaining first mass spectral data and automatically determining during an acquisition whether the first mass spectral data suffers from saturation or is approaching saturation. If a determination is made during an acquisition that the first mass spectral data suffers from saturation or is approaching saturation then the method further comprises automatically changing or altering the intensity of ions which are detected by an ion detector and obtaining second mass spectral data. The method further comprises substituting one or more portions of the first mass spectral data with one or more corresponding portions of the second mass spectral data multiplied or scaled by an attenuation or scale factor and/or by an integer or other value so as to form a composite mass spectrum, wherein the composite mass spectrum comprises one or more ion peaks from the first mass spectral data and one or more ion peaks from the second mass spectral data.

主权项

1. A method of mass spectrometry comprising:
transmitting ions and obtaining first mass spectral data; and automatically determining during an acquisition whether said first mass spectral data suffers from saturation or is approaching saturation; wherein if it is determined during an acquisition that said first mass spectral data suffers from saturation or is approaching saturation then said method further comprises: (i) automatically changing or altering the intensity of ions which are detected by an ion detector and obtaining second mass spectral data; and (ii) substituting one or more portions of said first mass spectral data with one or more corresponding portions of said second mass spectral data multiplied or scaled by an attenuation or scale factor or by an integer or other value so as to form a composite mass spectrum, wherein said composite mass spectrum comprises one or more ion peaks from said first mass spectral data and one or more ion peaks from said second mass spectral data.