| 发明名称 |
COMPOSITIONS AND METHODS FOR ADMINISTRATION OF VACCINES AGAINST DENGUE VIRUS |
| 摘要 |
Embodiments of the present invention report compositions and methods for vaccinating a subject against dengue viruses. In some embodiments, vaccine compositions may be administered by intradermal introduction. In certain embodiments, intradermal introduction in a subject of a vaccine against dengue virus may include one or more intradermal boosts after initial vaccination. Other embodiments include intradermal injection of a vaccine composition against dengue virus wherein the composition provides protection against two or more of DEN-1, DEN-2, DEN-3 and DEN-4. |
| 申请公布号 |
US2016129102(A1) |
申请公布日期 |
2016.05.12 |
| 申请号 |
US201514935281 |
申请日期 |
2015.11.06 |
| 申请人 |
Takeda Vaccines, Inc. |
发明人 |
STINCHCOMB Dan T.;OSORIO Jorge E.;PARTIDOS Charalambos D.;BREWOO Joseph N. |
| 分类号 |
A61K39/12;A61K9/00 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for inducing an immune response in a subject against all four dengue virus serotypes, comprising,
administering to the subject by at least a first introduction, an immunogenic composition of a mixture comprising components of all four live, attenuated dengue viruses, the composition comprising at least one dengue only chimera and at least a live, attenuated dengue-2 virus, and administering at least a second introduction of the immunogenic composition within 30 days after the first administration to the subject and inducing an immune response in the subject against all four dengue virus serotypes. |
| 地址 |
Deerfield IL US |
