发明名称 |
ANGIOTENSIN II ALONE OR IN COMBINATION FOR THE TREATMENT OF HYPOTENSION |
摘要 |
The present invention relates, inter alia, to a method comprising administering to a subject having high output shock and undergoing treatment with a catecholamine at a dose equivalent to at least about 0.2 mcg/kg/min of norepinephrine a dose of angiotensin II which is effective to raise the blood pressure of the subject to a mean arterial pressure (MAP) of about 65 mm or above, and which is effective to reduce the dose of the catecholamine required to maintain a MAP of about 65 mm to the equivalent of about 0.05-0.2 mcg/kg/min norepinephrine or less, or to the equivalent of about 0.05 mcg/kg/min norepinephrine or less. |
申请公布号 |
US2016129072(A1) |
申请公布日期 |
2016.05.12 |
申请号 |
US201514941301 |
申请日期 |
2015.11.13 |
申请人 |
The George Washington University a Congressionally Chartered Not-for-Profit Corporation |
发明人 |
Chawla Lakhmir |
分类号 |
A61K38/08;A61K31/135;A61K31/137 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
1. A method for maintaining a mean arterial pressure (MAP) of 65 mm Hg or above in a patient suffering from hypotension and undergoing treatment with vasopressin, comprising:
administering angiotensin II to the patient; and reducing the rate at which vasopressin is administered, while maintaining the MAP of the patient at about 65 mm Hg or above. |
地址 |
Washington DC US |