COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY

摘要

The present invention provides compositions and methods for immunotherapy, which include shelf-stable pharmaceutical compositions for inducing antigen-specific T cells. Such compositions are employed as components of an artificial antigen presenting cell (aAPC), to provide a patient with complexes for presentation of an antigen (e.g., a tumor antigen) and/or a T cell co-stimulatory molecule.

主权项

1. A pharmaceutical composition comprising:
polymeric PLGA-PEG particles having a size in the range of about 100 to 200 nm, a surface charge of about 0 to −20 mV, and from about 100 to 1500 protein ligands per particle, the protein ligands optionally coupled through a sulfhydryl-mateimide chemistry; a population of anti-CD28 antibody ligands; a population of HLA ligands; one or more antigenic peptides for presentation to T cells; and a pharmaceutically acceptable carrier for intravenous, intra-arterial, subcutaneous, intradermal, intralymphatic, or intra-tumoral administration.