CANCER IMMUNOTHERAPY USING VIRUS PARTICLES

摘要

A method of treating cancer in a subject in need thereof is described that includes administering a therapeutically effective amount of a virus or virus-like particle to the subject, wherein the virus particle is nonreplicating and noninfectious in the subject. The method represents a type of in situ vaccination, in which application of an immunostimulatory reagent directly to the tumor modifies the tumor microenvironment so that the immune system is able to respond to the tumor.