发明名称 |
CRYSTALLINE FORM OF JAK KINASE INHIBITOR BISULFATE AND A PREPARATION METHOD THEREOF |
摘要 |
The present invention relates to a crystal form of JAK kinase inhibitor bisulfate and a preparation method thereof. In particular, the present invention relates to a type II crystal of (3aR,5s,6aS)-N-(3-methoxy-1,2,4-thiadiazole-5-yl)-5-(methyl(7H-pyrrolo[2,3-d]pyrimidine-4-yl)amino)hexahydrocyclopenta[c]pyrrole-2(1H)-formamide bisulfate and a preparation method thereof. The preparation method comprises crystallizing any crystal forms or amorphous compound of formula (I) solid in a single organic solvent or a mixed organic solvent to obtain a type II crystal form of a compound of formula (I). The type II crystal form of compound of formula (I) obtained by the present invention has a good crystal stability and chemical stability, and the used crystal-solvent has a low toxicity and residue, which can be better used in clinical treatment. |
申请公布号 |
WO2016070697(A1) |
申请公布日期 |
2016.05.12 |
申请号 |
WO2015CN91527 |
申请日期 |
2015.10.09 |
申请人 |
JIANGSU HENGRUI MEDICINE CO., LTD. |
发明人 |
SUN, PIAOYANG;WU, GUAILI;ZHANG, QUANLIANG;CHEN, YONGJIANG;SHEN, LINGJIA |
分类号 |
C07D487/04;A61K31/519;A61P19/02;A61P29/00 |
主分类号 |
C07D487/04 |
代理机构 |
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