发明名称 |
SOLUBLE HETERODIMERIC T CELL RECEPTOR, AND PREPARATION METHOD AND USE THEREOF |
摘要 |
Provided is a high-stability T cell receptor (TCR). The TCR comprises (i) the whole or a part of TCRα chain except a transmembrane domain thereof, and (ii) the whole or a part of TCRβ chain except a transmembrane domain thereof, both the (i) and the (ii) comprising a functional variable domain and at least a part of a constant domain of a TCR chain. An artificial interchain disulfide bond links the constant domains of the TCRα and β chains, and a Tm value of the T cell receptor is greater than or equal to 45ºC. |
申请公布号 |
WO2016070814(A1) |
申请公布日期 |
2016.05.12 |
申请号 |
WO2015CN93806 |
申请日期 |
2015.11.04 |
申请人 |
GUANGZHOU XIANGXUE PHARMACEUTICAL CO., LTD. |
发明人 |
LI, YI;FAN, HUI |
分类号 |
C07K14/725;A61K38/17;A61P31/12;A61P35/00;A61P37/02;C12N1/21;C12N15/12;C12N15/63 |
主分类号 |
C07K14/725 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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