FOLATE-CONJUGATED MOLECULES FOR DELIVERY OF TOXIC SMALL MOLECULE INHIBITORS TO CANCER CELLS AND METHODS OF USE
摘要
The invention relates to novel derivatives of thapsigargin that are chemically modified with a group that targets a cell surface-expressed receptor, and pharmaceutical preparations thereof. The invention further relates to methods of treating diseases such as cancer using the compounds of the invention.
申请公布号
WO2016073708(A2)
申请公布日期
2016.05.12
申请号
WO2015US59222
申请日期
2015.11.05
申请人
DANA-FARBER CANCER INSTITUTE, INC.
发明人
BRADNER, JAMES;STEGMAIER, KIMBERLY;QI, JUN;VARCA, ANTHONY;ROTI, GIOVANNI