| 摘要 |
PROBLEM TO BE SOLVED: To provide 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment.SOLUTION: Provided are selected imidazo[1,2-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, where the 2' position of the nucleoside sugar is substituted with halogen and carbon substituents. The compounds, compositions and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and mutant strains of HCV.SELECTED DRAWING: None |
