ANTI-FACTOR VIII ANTIBODIES OR USES THEREOF

摘要

The present invention provides anti-FVIII antibodies and antigen-binding molecules thereof which specifically bind FVIII epitopes. The antibodies and antigen-binding molecules can be used to purify FVIII. The invention also includes nucleic acid molecules and methods of making the anti-FVIII antibodies or antigen binding molecules thereof.

主权项

1. An anti-FVIII antibody or antigen-binding molecule thereof which specifically binds to a Factor VIII (“FVIII”) epitope, wherein the antibody or antigen-binding molecule thereof exhibits one or more of the following characteristics:
(a) the anti-FVIII antibody or antigen-binding molecule thereof specifically binds to the same FVIII epitope as an antibody selected from MBS11, MBS32, MBS22, MBS14, GMA8023, GMA8024, GMA8045, GMA8025, GMA5G8, GMA8026, or MBS17; (b) the anti-FVIII antibody or antigen-binding molecule thereof competitively inhibits FVII binding by an antibody selected from MBS11, MBS32, MBS22, MBS14, GMA8023, GMA8024, GMA8045, GMA8025, GMA5G8, GMA8026, or MBS17; or (c) the anti-FVIII antibody or antigen-binding molecule thereof comprises at least one, at least two, at least three, at least four, or at least five complementarity determining regions (CDR) or variants thereof of an antibody selected from MBS11, MBS32, MBS22, MBS14, GMA8023, GMA8024, GMA8045, GMA8025, GMA5G8, GMA8026, or MBS17; wherein the FVIII epitope is located in an A2 domain, an A3 domain, a C1 domain, a C2 domain, or any combinations thereof; and wherein the anti-FVIII antibody or antigen binding molecule thereof is not GMA8002, GMA8005, GMA8004, GMA012, GMA8009, GMA8015, GMA8016, GMA8017, GMA8001, GMA8010, GMA8019, GMA8011, GMA8020, ESH4, ESH8, GMA8003, GMA8006, GMA8008, GMA8013, GMA8014, GMA8018, GMA8022, VIIISELECT®, N772-10M, or OBT-0037A.