GLYCAN-INTERACTING COMPOUNDS AND METHODS OF USE

摘要

The present invention provides glycan-interacting antibodies and methods for producing glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting antibodies include monoclonal antibodies, derivatives, and fragments thereof as well as compositions and kits comprising them. Further provided are methods of using glycan-interacting antibodies to target cells and treat disease.

主权项

1. A method of reducing tumor volume comprising administering an antibody to a subject in need thereof, wherein said antibody is administered at a dose of from about 0.25 mg/kg to about 25 mg/kg and wherein said antibody comprises a variable domain having an amino acid sequence comprising at least 95% amino acid sequence identity to an amino acid sequence selected from the group consisting of SEQ ID NOs: 15-52.