| 发明名称 |
NOVEL ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME |
| 摘要 |
The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder or disease. |
| 申请公布号 |
US2016130335(A1) |
申请公布日期 |
2016.05.12 |
| 申请号 |
US201514877617 |
申请日期 |
2015.10.07 |
| 申请人 |
Ruvo Menotti;Sandomenico Annamaria;Leonardi Antonio;Sanguigno Luca;Ann And Robert H. Lurie Children's Hospital Of Chicago |
发明人 |
Ruvo Menotti;Sandomenico Annamaria;Leonardi Antonio;Sanguigno Luca;Hendrix Mary J.C.;Seftor Elisabeth A.;Seftor Richard E.B.;Strizzi Luigi;Khalkhali-Ellis Zhila |
| 分类号 |
C07K16/22 |
主分类号 |
C07K16/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An anti-Nodal monoclonal antibody; wherein the antibody:
(a) binds the Nodal pre-helix loop region; (b) binds to full length human Nodal; (c) inhibits Nodal binding to Cripto-1; and (d) does not bind to an E49A/E50A variant of Nodal. |
| 地址 |
Caserta IT |
