RESTORING PHYSIOLOGY WITH SMALL MOLECULE MIMICS OF MISSING PROTEINS
摘要
Disclosed are methods for treating a disease or condition characterized by decreased expression or reduced function of an ion channel, comprising administering to a subject in need thereof a therapeutically effective amount of a pore-forming polyene macrolide or pore-forming derivative thereof. For example, the pore-forming polyene macrolide may be amphotericin B (AmB), nystatin, or natamycin. The methods can be used to treat cystic fibrosis.
申请公布号
WO2016073462(A1)
申请公布日期
2016.05.12
申请号
WO2015US58806
申请日期
2015.11.03
申请人
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人
BURKE, MARTIN, D.;CIOFFI, ALEXANDER, G.;DIAZ, KATRINA, A.;HOU, JENNIFER;GRILLO, ANTHONY, S.