| 主权项 |
1. A compound of formula (XVI), or salt thereof, wherein: R1 is fluoro; R2 is fluoro; each R4 is independently aryl substituted with 0, 1, 2 or 3 independent R8; R5 is H, alkyl, phosphato, phosphito, alkoxyphosphato, or —C(O)alkyl optionally substituted with 1 or 2 amino; each R8 is independently optionally substituted alkyl, cyano, haloalkyl, alkoxy, halo, or haloalkoxy; each R35 is independently each X is independently O or S; each Y is independently OH, NH2, or NH—SO2—R17; each n is independently 1, 2, or 3; each o is independently 0, 1, 2, or 3; each p is independently 0, 1, 2, or 3; each t is independently 0, 1, 2, or 3; each R14 is independently:
a) alkyl substituted with 1, 2, or 3 independent OH, haloalkoxy, optionally substituted heterocyclo, optionally substituted heteroaryl, b) alkoxy substituted with 0, 1, 2, or 3 independent OR17 or c)or
d) optionally substituted heterocyclo; each R32 is independently:
a) haloalkyl;b) halo;c) alkyl substituted with 0, 1, 2, or 3 independent OH, haloalkoxy, optionally substituted heterocyclo, optionally substituted heteroaryl,or
d) each R16 is independently:
a) aralkyl substituted with 0, 1, 2, or 3 independent:
(1) cyano;(2) halo;(3) (4) alkoxy;(5) haloalkyl;(6) haloalkoxy;(7) optionally substituted alkyl;(8) optionally substituted aryl;(9) optionally substituted heteroaryl; or(10) optionally substituted heterocyclyl;b) OR17; orc) optionally substituted aryl; each R17 is independently H, optionally substituted alkyl, haloalkyl, or each R18 is independently:
a) aryl substituted with 0, 1, 2, or 3 independent:
(1) halo;(2) haloalkyl;(3) alkoxy;(4) haloalkoxy;(5) optionally substituted cycloalkyl;(6) optionally substituted heterocyclyl;(7) optionally substituted alkyl;(8) (9) OR19;(10) SR19;(11) optionally substituted heteroaryl; or(12) cyano;b) optionally substituted cycloalkyl;c) optionally substituted heteroaryl;d) optionally substituted heterocyclyl;e) optionally substituted alkyl;f) optionally substituted cycloalkylalkyl;g) optionally substituted cycloalkylalkoxy;h) haloalkyl;i) haloalkoxy; j) haloalkoxyalkyl; k)or
l) optionally substituted aralkyl; each R19 is independently H, optionally substituted alkyl, or haloalkyl; each R20 is independently H, optionally substituted alkyl, or each R33 is independently H, optionally substituted heteroaryl, optionally substituted alkyl, optionally substituted haloalkyl, optionally substituted alkylcarbonyl, or R22 is independently:
a) b) optionally substituted alkyl;c) optionally substituted aryl;d) optionally substituted heteroaryl;e) optionally substituted cycloalkyl; orf) optionally substituted heterocyclyl; and each R25 is independently optionally substituted aryl; optionally substituted arylalkyl, haloalkoxy, (haloalkoxy)alkyl, cycloalkyl, alkyl, —CH2CF2CF3, —CF2CF3, or. |
