发明名称 |
Quinazoline Derivatives as VEGF Inhibitors |
摘要 |
The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R1 represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the following three groups: 1) C1-5alkylR3 (wherein R3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy; 2) C2-5alkenylR3 (wherein R3 is as defined hereinbefore); 3) C2-5alkynylR3 (wherein R3 is as defined hereinbefore); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; and salts thereof; processes for their preparation, pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.; |
申请公布号 |
US2016130249(A1) |
申请公布日期 |
2016.05.12 |
申请号 |
US201514719779 |
申请日期 |
2015.05.22 |
申请人 |
ASTRAZENECA AB |
发明人 |
Thomas Andrew Peter;Stokes Elaine Sophie Elizabeth;Hennequin Laurent Francois Andre |
分类号 |
C07D401/12 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
1. A quinazoline derivative of the formula I: wherein: m is an integer from 1 to 3; R1 represents halogeno or C1-3alkyl; X1 represents —O—; R2 is selected from one of the following three groups: 1) C1-5alkylR3 (wherein R3 is piperidin-4-yl which may bear one or two substituents selected from hydroxy, halogeno, C1-4alkyl, C1-4hydroxyalkyl and C1-4alkoxy; 2) C2-5alkenylR3 (wherein R3 is as defined herein); 3) C2-5alkynylR3 (wherein R3 is as defined herein); and wherein any alkyl, alkenyl or alkynyl group may bear one or more substituents selected from hydroxy, halogeno and amino; or a salt thereof. |
地址 |
Sodertalje SE |