发明名称 NON-DIGESTIBLE OLIGOSACCHARIDES FOR ORAL INDUCTION OF TOLERANCE AGAINST DIETARY PROTEINS
摘要 Compositions and methods for providing infant nutrition with partially hydrolysed proteins and non-digestible oligosaccharides for use in induction of oral tolerance against native dietary proteins.
申请公布号 US2016129024(A1) 申请公布日期 2016.05.12
申请号 US201614995345 申请日期 2016.01.14
申请人 N.V. NUTRICIA 发明人 Knippels Léon Mathieu Johannes;van Esch Elisabeth Catharina Adriana Maria;Garssen Johan
分类号 A61K31/702;A61K38/10;A61K39/35 主分类号 A61K31/702
代理机构 代理人
主权项 1. A method for enhancing a partial protein hydrolysate-induced oral immune tolerance against dietary proteins in a subject in need thereof, said method comprising administering to said subject at least one non-digestible oligosaccharide selected from the group consisting of fructo-oligosaccharide, non-digestible dextrin, galacto-oligosaccharide, xylo-oligosaccharide, arabino-oligosaccharide, arabinogalacto-oligosaccharide, gluco-oligosaccharide, glucomanno-oligosaccharide, galactomanno-oligosaccharide, mannan-oligosaccharide, chito-oligosaccharide, uronic acid oligosaccharide, sialyloligosaccharide and fuco-oligosaccharide, wherein the partial protein hydrolysate comprises at least 3 wt % of peptides with a size of 5 kDa or above and at least 50 wt. % of peptides with a size below 5 kDa and wherein the partial protein hydrolysate is partial mammalian milk protein hydrolysate, partial whey protein hydrolysate or partial beta-lactoglobulin hydrolysate, such that partial protein hydrolysate-induced oral immune tolerance against dietary proteins is enhanced in said subject.
地址 HM Zoetermeer NL