VALVE AND SPLITTING SYSTEM FOR MULTI-DIMENSIONAL LIQUID ANALYSIS

摘要

A multi-dimensional liquid analysis system includes a flow splitter for separating mobile phase outflow from a first dimension liquid analysis system into fist and second liquid split outlet flows. Volumetric flow rate control of the split outlet flows is provided by a flow control pump which withdraws one of the split outlet flows from the flow splitter at a controlled withdrawal flow rate to define the other split outlet flow rate as the difference between the outflow rate from the first dimension system and the withdrawal flow rate. In this manner, accurate and consistent flow division can be accomplished, which is particularly useful for multi-dimensional liquid analysis.

主权项

1. A multi-dimensional liquid analysis system, comprising:
a first separation system including a first separation column, the first separation column configured to chromatographically separate a liquid mobile phase into a first dimension outflow having a first outflow rate; a flow splitter fluidly coupled to the first dimension outflow, the flow splitter configured to separate the first dimension outflow into a first split outlet flow and a second split outlet flow; a second separation system including a second separation column, the second separation column configured to chromatographically separate the second split outlet flow; and a flow controller fluidly coupled to one of the first split outlet flow and the second split outlet flow, the flow controller configured to control a flow rate of the one of the first split outlet flow and the second split outlet flow from the flow splitter.