主权项 |
1. A method for establishing a process for screening vitamin D (Vit-D) insufficiency in a population of interest, comprising
determining a Vit-D status of a cohort of subjects of the population by measuring serum 25(OH)Vit-D level, wherein serum 25(OH)Vit-D level≦50 nmol/L indicates Vit-D insufficiency, and serum 25(OH)Vit-D level>50 nmol/L indicates Vit-D sufficiency, and wherein Vit-D insufficiency status is designated a value of “1” and Vit-D sufficiency status is designated a value of “0”; obtaining a set of factors including constitutive skin melanin pigmentation measurement (Vf) and facultative skin melanin pigmentation measurement (Vh) in an individual subject, and one selected from the group consisting of: an age, a season, a gender, a body weight (BW), a standing height (SH), a physical activity level (PAL), a daily dietary Vit-D intake (Dvd), a daily dietary calcium intake (Dca), or any combination thereof in the individual subject, or transformed formats of the factors, wherein Vf is measured using skin colourimetry on an instep area, an inner aspect or a sole of a foot, or a heel of the individual subject, Vh is measured using skin colourimetry on a dorsum of a hand, fingers, a thumb or a wrist of the individual subject, the age, the BW, the SH, the PAL, the Dvd or the Dca is determined from the individual subject, the seasons are differentially designated pre-set values, and the genders are differentially designated pre-set values, and carrying out a logistic regression analysis by using a Vit-D status as a dependent variable, and the factors or the transformed formats of the factors as independent variables, thereby obtaining a function as shown below with regression coefficients for each of the independent variables:loge(Pred1-Pred)=α+∑1kβixi, wherein α is a constant term, βi is a regression coefficient for an independent variable xi, xi represents the individual independent variables, k represents a total number of the independent variables, Pred is a predicted probability used for determining a screening result of either Vit-D insufficiency or Vit-D sufficiency according to a pre-set cut-off threshold of Pred. |