| 摘要 |
Compositions and methods for managing the growth, life cycle, functionality, or biological progression of cells, tissues, and organisms by introducing rhomboid proteins or peptides into the internal and external environment of the cells, tissues, and organisms. In particular, embodiments comprise compositions and methods for overcoming drug resistance in disease, and for sensitizing cells, tissues, and organisms to agents to treat disease, and methods for producing such compositions. The compositions and methods include rhomboid proteins, polypeptides, and/or peptides, and nucleic acids encoding such proteins, polypeptides, and/or and peptides, corresponding to the Arabidopsis At1g74130 or At1g25290 gene or human UBAC2 gene. The rhomboid proteins, polypeptides, and/or and peptides or nucleic acids may be derived from natural genetic sources, from different species, different genes of the rhomboid family, through alternative splicing of encoding transcripts, through laboratory manipulations, using recombinant protein production techniques, fermentation, mutagenesis approaches, synthesis, peptides, or other methods of generation and production. |
| 主权项 |
1. A method for enhancing efficacy of an agent, comprising:
co-administering to a cell, tissue, organ, or organism the agent in a therapeutic or sub-therapeutic dose and a rhomboid protein, polypeptide, or peptide, in a suitable vehicle; wherein the rhomboid protein is selected from At1g74130, At1g25290, and UBAC2 protein or a splice variant thereof, or the rhomboid polypeptide or peptide is derived from At1g74130, At1g25290, or UBAC2 protein or a splice variant thereof, or is a functional equivalent thereof; wherein said co-administration enhances efficacy of the agent in the cell, tissue, organ, or organism. |
