| 发明名称 |
COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION |
| 摘要 |
Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described. |
| 申请公布号 |
US2016130563(A1) |
申请公布日期 |
2016.05.12 |
| 申请号 |
US201414898083 |
申请日期 |
2014.06.16 |
| 申请人 |
OTTAWA HOSPITAL RESEARCH INSTITUTE |
发明人 |
ILKOW Carolina Solange;LE BOEUF Fabrice;BELL John Cameron;DIALLO Jean-Simon;ARULANANDAM Rozanne |
| 分类号 |
C12N7/00;C07K14/50 |
主分类号 |
C12N7/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein, the method comprising administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. |
| 地址 |
Ottawa CA |
