Modular Microtube Network for Vascularized Organ-On-A-Chip Models

摘要

A perfusable, microtube-based flow system for microdevice models of human tissues and organs includes a microfluidic chip with a network of microtubes passing through at least one common chamber space suitable to hold cells of an appropriate organ and/or a biocompatible support matrix. The microtube model network can be used to create model tissues and organs for study and research.

主权项

1. A model microtube network comprising:
at least one microtube comprising a permeable wall surrounding a central hollow lumen open at opposing ends of the microtube, wherein the microtube has an outer diameter of between 5 and 8000 microns and the permeable wall has a thickness of between 0.1 and 250 microns with a pore size of from 0.1 microns to 500 microns; and a microfluidic chip having a chamber space defined by chamber walls, wherein the at least one microtube passes through the chamber space and through the chamber walls with the lumen open at each end outside the chamber space.