Controlled Photomechanical and Photothermal Treatment of Mucosal Tissue

摘要

Systems and methods for treating mucosal tissue by concentrating a laser emission to at least one depth at a fluence sufficient to create an ablation volume in at least a portion of the mucosal tissue and controlling pulse width within the picosecond regime to provide a desired mechanical pressure in the form of shock waves and/or pressure waves.

主权项

1. A method for tissue treatment, comprising:
providing a picosecond laser having a wavelength between about 532-1064 nanometers (nm), a pulsewidth of about 100 to 750 picoseconds (ps), and a fluence of about 20-80 joules per square centimeter (J/cm̂2); delivering light from the picosecond laser to a target region comprising mucosal tissue; and causing laser induced optical breakdown in the target region by exceeding the electron avalanche breakdown threshold of the mucosal tissue, the laser induced optical breakdown stimulating autonomous tissue regeneration in the target region.