| 摘要 |
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/063401 Al 2 May 2013 (02.05.2013) WI PO I PCT (51) [nternatonal Patent Classification: (74) Agents: BUTEAU, Kristen C. e, al.; Choate, Hall & AOIN 43/54 (2006.01) Stewart LLP, Two buermational Place, Bosion, MA 02110 (21) International Application Number: (US) PCT/US2012/062133 (81) Designated States (unless otherwise indicated, for eren kind of national protection available): AE, AG, AL, AM, (22) International iIlg Date: AO, AT, AU, AZ, BA, BB, BG, BH BN, BR, BW, BY, 26 October 2012(26,10.2012) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, HN, HR, H., ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (26) Publication Language: English KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (30) Priorlty Data: ME, MG, MK, MN, MW. MX, MY, MZ, NA, NO, NI, 61/552,936 28 October 2011(28.10.201 1) US NO, NZ, OM, PA, PE, PG, PI, PL, PT, QA, RO, RS, RU, 61/569,475 12 December 20l (12.12201 1) US RW, SC, SD, SE, SO, SK, SL, SM, ST, SV, SY, TH, Ti, 61/592,351 30fJaniary 2012 (30.01.2012) US TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, 61/593,056 31 January 2012(31.01.2012) US ZM, ZW. 61/604,780 29 February 2012 (29.02.2012) US (84) Dsignated States unless otherwise indicated. fr evrn 61/618,347 30 March 2012 (30.03.2012) US kind of regional protection available): ARIPO (BW, GH, 61/649,450 21 May 2012 (21.05.2012) US GM, KE, LR, LS, MW, MZ, NA, RW. SD. SL, SZ, TZ. 61/660,319 15 June 20J2 (15.06.2012) US UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, Ti, (71) Applicant: CELGENE AVILOMICS RESEARCH, TM). European (AL. AT, BE. BG. CH. CY, CZ, DE, DK, INC. [US/US]; 45 Wiggins Avenue, Bedford, MA 01730 IE, ES, FI, PR, GB, OR, HR, U, liE IS, IT, LT, LU, LV, (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR) OAPI (BF, 1BI, CF, CG, Cl, CM, GA, ON, GQ, GW, (72) Inventors: WITOWSKI, Steven, Richard; 171 Laurel ML. MR. NE. SN, TD. TO). Street, Melrose, MA 02176 (US). WESTLIN. William. Frederick; 130 Barean Lane, Boxborough, MA 01719 (US). LOUNSBURY, Heaher; 41 Sunset Drive, Fram- - .ihnerntional search report (Art. 21(3)) ingham, MA 01701 (US). STIEDE, Kathryn; 49 Nevins Road, Hollis, NH 03049 (US). SILVER, Bruce, A.; 12132 Palisades Drive. Dunkirk, MD 20754-9430 (US). MEl, Jay, M.; 1373 Perry Circle, North Wales, PA 19454 (US). (54) Title: METHODS OF TREATING A BRUTON*S TYROSINE KINASE DISEASE OR DISORDER (57) Abstract: The present invention provides methods oftreating, stabilizing or lessening the severity or progression of a disease or disorder associated with FK. |
