| 摘要 |
A diagnostic apparatus for in vivo diagnosis of disease, optionally an ophthalmological disease and/or a tumour. The apparatus comprises: a monochromator 6 configured to receive light containing a range of wavelengths and create a plurality of substantially continuous bandwidths of light across an excitation range of a biological target 14; a direction means configured to focus the light created by the monochromator on the target in vivo; a detection means 24 configured to detect autofluorescence emitted by the target upon exposure to each bandwidth; and a processing means 26 configured to diagnose disease based upon the detected autofluorescence. The apparatus may be configured to diagnosis a tumour situated on the skin or in a lung. The direction means may focus the monochromator light on the eye or eyelid for diagnosing an ophthalmological disease based upon detected autofluorescence. The apparatus may be configured to detect one or more micro-organisms such as amoeba, bacterium such as Staphylococcuss, Escherichia, Pseudomonas, or fungus such as Fusarium, Candida. The detection- means may disperse the autofluorescence into a spectrum used by the processing-means to diagnose the disease, where the processing-means may provide the autofluorescent spectra as Excitation-Emission Matrix (EEM) measurements. Also disclosed a bronchoscope. |
