发明名称 |
所定の標的に対して親和性を有するヒトリポカリン2(Lcn2、hNGAL)の突然変異タンパク質 |
摘要 |
The present invention relates to a novel library for the generation of muteins and to novel muteins derived from human lipocalin 2 (Lcn2, hNGAL) and related proteins that bind a given target with detectable affinity. The invention also relates to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. For example, such muteins may serve to bind and deplete pathological forms of natural biomolecules such as the amyloid beta peptide in Alzheimer's disease or may target the fibronectin extra-domain B, which is associated with tumor neovasculature. |
申请公布号 |
JP5913120(B2) |
申请公布日期 |
2016.05.11 |
申请号 |
JP20120542505 |
申请日期 |
2010.12.07 |
申请人 |
ピエリス アーゲーPIERIS AG |
发明人 |
スケラ アルネ;ゲバウエル ミヒャエルラ;ヒンツ ドミニク;ラウト サビネ;マツィヒナー ガブリエレ;ヒュルスマイアー マルティン |
分类号 |
C12N15/09;A61K38/00;A61P25/28;C07K14/47;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02;G01N33/53 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|