发明名称 |
NOVEL COMPOUND HAVING ABILITY TO INHIBIT 11B-HSD1 ENZYME OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT |
摘要 |
The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof inhibiting 11²-HSD1 enzyme activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. Since the compound of the present invention selectively inhibits the activity of 11²-HSD1 (11²-Hydroxysteroid dehydrogenase type 1), the compound of the invention can be effectively used as a therapeutic agent for the treatment of diseases caused by the over-activation of 11²-HSD1 such as non-insulin dependent type II diabetes, insulin resistance, obesity, lipid disorder, metabolic syndrome, and other diseases or condition mediated by the excessive activity of glucocorticoid. |
申请公布号 |
EP2865664(A4) |
申请公布日期 |
2016.05.11 |
申请号 |
EP20130806654 |
申请日期 |
2013.06.04 |
申请人 |
BAMICHEM CO., LTD;AHN-GOOK PHARMACEUTICAL CO., LTD.;INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION |
发明人 |
HAN, CHEOL KYU;AUH, JIN;CHOI, NAM SONG;HAN, CHANG KYUN;KIM, TAE-JEONG;PAE, KAMSA;SHIN, YOUNG JUNE;HAN, DONG-OH;AHN, SOON KIL |
分类号 |
C07C311/29;A61K31/18;A61P3/10 |
主分类号 |
C07C311/29 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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