发明名称 |
METHOD FOR PREPARING VIROSOMES |
摘要 |
Described are methods for preparing virosomes comprising the steps of: (a) providing an enveloped virus, and optionally inactivating the virus; (b) solubilizing the viral envelopes in a first solubilizing agent; (c) pre-solubilizing exogenous components in a second solubilizing agent; (d) adding the pre-solubilized exogenous components to the solubilized viral envelopes; and (e) reconstituting virosomal membranes by removing the solubilizing agent. According to the disclosure, the viral envelopes and the exogenous components are (pre-)solubilized at a temperature below 33° C. |
申请公布号 |
EP3016679(A1) |
申请公布日期 |
2016.05.11 |
申请号 |
EP20140734798 |
申请日期 |
2014.06.30 |
申请人 |
CRUCELL HOLLAND B.V. |
发明人 |
DONG, WENYU;RIJKEN, PIETER;UGWOKE, MIKE |
分类号 |
A61K39/12;A61K9/127;A61K39/145 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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