| 摘要 |
This document relates to fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain. In particular, a composition comprising: a ColH or ColG bacterial collagen-binding polypeptide segment linked to a PTH/PTHrP receptor modulator; wherein the PTH / PTHrP receptor modulator is an agonist of the PTH/PTHrP receptor and comprises a sequence selected from the group consisting of residues 1-33 of SEQ ID NO: 1, PTH (SEQ ID NO: 7), residues 1-14 of SEQ ID NO: 1, residues 1-34 of SEQ ID NO: 7 and SEQ ID NO: 8; or wherein the PTH / PTHrP receptor modulator is an antagonist of the PTH/PTHrP receptor and comprises a sequence selected from the group consisting of residues 7-34 of SEQ ID NO: 7, residues 7-14 of SEQ ID NO: 7, residues 7-33 of SEQ ID NO: 7, residues 7-34 of SEQ ID NO: 8, and SEQ ID NO: 11. |
