| 摘要 |
The present invention provides a process for preparing cycloheptene and derivatives thereof by ring-closure metathesis of asymmetric 1,8-dienes whose C-C double bond in position 8 is not terminal. Cycloheptene and also its derivatives cycloheptanone, cycloheptylamine, cycloheptanecarbaldehyde, cycloheptanecarboxylic acid and cycloheptanecarbonyl chloride, and also their derivatives, are important synthetic building blocks for active compounds. The ring-closure metathesis is performed preferably as a reactive distillation. The asymmetric 1,8-dienes for the ring-closure metathesis can be obtained by catalytic decarbonylation or oxidative decarboxylation of the corresponding unsaturated carboxylic acids and/or carboxylic acid derivatives. |
