发明名称 |
METHOD FOR ASSIGNING TARGET-ENRICHED SEQUENCE READS TO A GENOMIC LOCATION |
摘要 |
Provided herein, among other things, is a computer-implemented method for assigning a sequence read to a genomic location, the method including: a) accessing a file containing a sequence read, wherein the sequence read is obtained from a nucleic acid sample that has been enriched by hybridization to a plurality of capture sequences; and b) assigning the sequence read to a genomic location by: i) identifying a capture sequence as being a match with the sequence read if the sequence read contains one or more subsequences of the capture sequence; ii) calculating, using a computer, a score indicating the degree of sequence similarity between each of the matched capture sequences and the sequence read; and iii) assigning the sequence read to the genomic location if the calculated score for a matched capture sequence is above a threshold. |
申请公布号 |
EP3018604(A1) |
申请公布日期 |
2016.05.11 |
申请号 |
EP20150192572 |
申请日期 |
2015.11.02 |
申请人 |
AGILENT TECHNOLOGIES, INC. |
发明人 |
LE COCQ, CHRISTIAN A.;ISAKSSON, MAGNUS;LNU, ASHUTOSH;FORSMARK, LINUS |
分类号 |
G06F19/22;G06F19/20 |
主分类号 |
G06F19/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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