| 主权项 |
1. A compound of formula (I)or a pharmaceutically acceptable salt thereof, wherein
p is 1 or 2; is a single or double bond; R1 is m is 0, 1, or 2; one of X and X′ is N and the other is selected from CH and CR3′; R2, R2′, R3, and R3′ are independently selected from hydrogen, alkoxy, alkyl, aryl, halo, haloalkyl, and heteroaryl, wherein the aryl and heteroaryl are optionally substituted with one group independently selected from alkoxy and alkyl; Rx is selected from methyl and ethyl; Ry and Rz are independently selected from hydrogen and hydroxy; provided that when is a double bond, Ry and Rz are each hydrogen; R4 is selected from hydrogen, alkyl, and halo, haloalkoxy, haloalkyl, and hydroxyalkyl; R5 is selected from hydrogen, alkoxyalkoxycarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonyl, cycloalkylalkoxycarbonyl, cycloalkylcarbonyl, cycloalkyloxycarbonyl, deuteroalkoxycarbonyl, deuterohaloalkoxycarbonyl, dialkylaminocarbonyl, dialkylaminocarbonylcarbonyl, haloalkoxycarbonyl, haloalkylaminocarbonyl, haloalkylcarbonyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, phenylcarbonyl, and phenyloxycarbonyl, wherein the cycloalkyl part of the cycloalkylalkoxycarbonyl, the cycloalkylcarbonyl, and the cycloalkyloxycarbonyl, the heterocyclyl part of the heterocyclylcarbonyl and the heterocyclyloxycarbonyl, and the phenyl part of the phenylcarbonyl and the phenyloxycarbonyl, is optionally substituted with one, two, or three groups independently selected from alkyl, alkylamino, alkylcarbonyl, cycloalkyl, dialkylamino, halo, haloalkoxy, and haloalkyl;and
one of Y and Y′ is CH2 and the other is selected from CH2 and O. |
