POLYPEPTIDES CONTAINING Fc-SECTION THAT DISPLAY INCREASED EFFECTOR FUNCTION OWING TO VARYING FUCOSYLATION LEVEL AND THEIR APPLICATIONS

摘要

FIELD: biotechnologies.SUBSTANCE: claimed invention discloses the attenuation of post-translational fucosylation of the molecule containing a modified Fc-section. The claimed process comprises the Fc-section modification, molecule-candidate expression, evaluation of the ratio between the glycosylation of oligosaccharides with the high content of mannose and the glycosylation of complex oligosaccharides and identification of the molecule-candidate as a suitable one at the ratio over 0.2. The proposed invention can be used in medicine.EFFECT: higher efficiency of purification.15 cl, 95 dwg, 35 tbl, 7 ex