| 发明名称 | Compositions and methods for characterizing a myopathy | ||
| 摘要 | The invention provides compositions, methods, and kits diagnosing, monitoring, and otherwise characterizing a myopathy and for detecting the presence of autoantibodies in a biological sample. | ||
| 申请公布号 | US9335326(B2) | 申请公布日期 | 2016.05.10 |
| 申请号 | US201414283638 | 申请日期 | 2014.05.21 |
| 申请人 | The Johns Hopkins University | 发明人 | Casciola-Rosen Livia A.;Christopher-Stine Lisa;Mammen Andrew;Rosen Antony |
| 分类号 | G01N33/53;G01N33/573;G01N33/564 | 主分类号 | G01N33/53 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless Peter F.;Emmons Richard B. |
| 主权项 | 1. A method for diagnosing a myopathy comprising: providing a kit having a 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) protein or a fragment thereof having HMGCR autoantibody binding activity fixed to a solid phase; and contacting the HMGCR protein or fragment thereof with a sample from a subject suspected of having HMGCR autoantibodies, wherein sample binding to the HMGCR protein or fragment thereof indicates that the subject has a myopathy. | ||
| 地址 | Baltimore MD US | ||