Method of reducing recurrence of multiple sclerosis symptoms in a mammal by administering an anti-repulsive guidance molecule neutralizing antibody

摘要

Provided is a T cell activation inhibitor containing an RGM inhibiting substance such as an anti-RGM neutralizing antibody and the like as an active ingredient. The T cell activation inhibitor is useful as a pharmaceutical composition for the prophylaxis or treatment of autoimmune diseases such as multiple sclerosis and the like, and other diseases caused by T cell activation. In addition, a T cell activation inhibiting substance can be screened for by contacting a test substance with RGM and selecting a test substance that lowers the activity level of RGM.

主权项

1. A method of reducing recurrence of an episode of multiple sclerosis symptoms in a mammal, comprising administering an effective amount of a T cell activation inhibitor comprising an anti-Repulsive Guidance Molecule (RGM) neutralizing antibody as an active ingredient to a mammal having multiple sclerosis, wherein the anti-RGM neutralizing antibody is administered in the latter stage of paralysis expression stage, thereby reducing recurrence of an episode of multiple sclerosis symptoms in the mammal.