Devices and methods for shape-based particle separation

摘要

A particle sorting system includes an inlet and an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, wherein the inlet is connected to an upstream end of the microchannel. A source of different shaped particles is connected to the inlet, wherein the source of different shaped particles are configured for continuous introduction into the inlet. A plurality of outlets is connected to the microchannel at the downstream expanding region. Fluidic resistors are located in the respective outlets. Different resistances may be used in the outlets to capture enriched fractions of particles having particular particle shape(s).

主权项

1. A particle sorting system, comprising:
an inlet; an inertial focusing microchannel disposed in a substrate and having a downstream expanding region with an increased cross-sectional area at a distal end, wherein the inlet is connected to an upstream end of the microchannel, wherein the inertial focusing microchannel and the downstream expanding region define flow paths uninterrupted by obstacles; a source of different shaped particles connected to the inlet, wherein the source of different shaped particles are configured for continuous introduction into the inlet; a plurality of outlets connected to the microchannel at the downstream expanding region, with the plurality of outlets located at different lateral positions at the downstream expanding region; and a pressure controller connected to the plurality of outlets via fluid lines, wherein the pressure controller applies variable pressures to adjust the respective fluid resistance at the plurality of outlets.