FGFR1 antibodies and treatment of cancer

摘要

The use of an FGFR1 antibody in the treatment of cancer is disclosed, wherein the FGFR1 antibody binds FGFR1 at an epitope that is positioned in the FGFR1 primary amino acid sequence no more than 50 contiguous amino acids away from the C- or N-terminal of the FGFR1 heparin binding domain.

主权项

1. A method of treating a cancer in a subject in need of treatment, the method comprising administering an FGFR1 antibody to the subject, wherein the FGFR1 antibody binds FGFR1 at an epitope consisting of an amino acid sequence having less than 20 amino acids and at least 8 contiguous amino acids of the amino acid sequence SSSEEKETDNTKPNR [SEQ ID NO:2], and wherein cells in the cancer express FGFR1 on the cell surface.