PHARMACEUTICAL COMPOSITION OF EXTENDED RELEASE OF MORPHOLINIUM [(5-METHYL-1H-1,2,4-TRIASOL-3-YL)THIO]ACETATE

摘要

The invention relates to the pharmaceutical composition of extended release containing the active ingredient and at least one matrix-forming polymer agent selected from polyethylene oxide with molecular weight in the range of 100,000 to 10,000,000 Daltons and hydroxypropyl methylcellulose with nominal viscosity in the range of 3 to 100,000 mPa • s, in combination with one or more pharmaceutically acceptable excipients, and the active ingredient represents morpholine salt of thionitric acid with particle size less than 500 microns, and the active ingredient and matrix-forming polymer agent contained at a 1:0.2-1.9 ratio.