Adhesive patch

摘要

Provided is an adhesive patch which has excellent rivastigmine storage stability and an increased skin permeability of rivastigmine to such an extent that the amount of percutaneous absorption required for treating Alzheimer's disease is obtained.;This adhesive patch includes a backing and an adhesive layer containing rivastigmine and an alkyl (meth)acrylate-based copolymer that does not contain any acrylic monomer component having a carboxy group, the adhesive layer being laid on one side of and integrated with the backing.

主权项

1. An adhesive patch comprising: a backing; and an adhesive layer containing rivastigmine and an alkyl (meth)acrylate-based copolymer without containing any acrylic monomer component having a carboxy group, the adhesive layer being laid on one side of and integrated with the backing,
wherein the alkyl (meth)acrylate-based copolymer includes a copolymer containing a 2-ethylhexyl acrylate component, a 2-ethylhexyl methacrylate component and an alkyl (meth)acrylate component having an alkyl group with six or more carbon atoms except 2-ethylhexyl (meth)acrylate, wherein a total amount of the 2-ethylhexyl acrylate component and the 2-ethylhexyl methacrylate component is from 40 to 95% by weight of the copolymer, and an amount of the alkyl (meth)acrylate component having an alkyl group with six or more carbon atoms except 2-ethylhexyl (meth)acrylate is from 5 to 60% by weight of the copolymer.