Method for pre-screening and correlation of underlying SCARB1 gene variation to infertility in women and therapeutic use of progestational and other medications in treatment

摘要

A method of genotyping women experiencing infertility for non-physical reasons in order to identify the presence of the rs4238001 and/or rs10846744 mutation of the SCARB1 gene and, upon identifying the presence of one or both genetic mutations, administering a tailored therapeutic regimen to restore fertility by either one or a combination of 1) mediating the flux of cholesterol resulting from the mutation by therapeutic use of the cholesterol medication probucol and/or other cholesterol altering medications, and/or 2) amplifying the presence of hormone progesterone by therapeutic use of progestational and progestin medications.

主权项

1. A method for treating infertility in a human adult female subject comprising the steps of:
a) confirming that the human adult female subject has been medically diagnosed with infertility, b) performing a medical examination to eliminate physical obstruction as a cause of said diagnosed infertility in said human adult female subject, c) obtaining a whole blood sample from said human adult female subject, d) purifying said whole blood sample, e) isolating nucleic acid from said purified blood sample, f) conducting a genetic gest on said isolated nucleic acid, comprising a microarray assay or a fluorescent allele specific polymerase chain reaction (PCR) based assay that detects the allele for the rs4238001 polymorphism in the SCARB1 gene in said human adult female subject, g) detecting the A allele for rs4238001 in said isolated nucleic acid from said human adult female subject, h) administering a pharmacologically effective regimen of probucol to said human adult female subject to mediate cholesterol in said human adult female subject's bloodstream.