Organic-inorganic hybrid composite of polymerized nitroxide compound and inorganic particles

摘要

Provided is an organic-inorganic hybrid composite of a polymerized cyclic nitroxide radical compound and inorganic nanoparticles. Such a composite is capable, for example, of maintaining a stable nanoparticle shape in gastric fluid, and can be used by itself or as a carrier for delivery of another drug to the intestines.

主权项

1. An organic-inorganic hybrid composite comprising inorganic particles and a polymer,
wherein the inorganic particles are selected from the group consisting of silica particles and magnetic particles, and the polymer is a block copolymer represented by Formula (I):
PEG-CNR   (I) in which PEG is a segment containing poly(ethylene glycol), and CNR is a polymer segment having a repeating unit containing, as part of a pendant group, a cyclic nitroxide radical that binds to a polymer main chain via a linking group, and wherein the hybrid composite is, when dissolved or dispersed in water, in the form of a polymer micelle having an average particle diameter of 5 nm to 500 nm.