| 发明名称 | Compositions and methods to elicit immune responses against pathogenic organisms using yeast-based vaccines | ||
| 摘要 | Embodiments of the present invention illustrate methods of treating and preventing infection due to a pathogen such as a fungal pathogen. In particular, the present invention relates to compositions and methods for vaccinations against or treatment for a fungal organism in a non-immunocompromised or immunocompromised subject. | ||
| 申请公布号 | US9333246(B2) | 申请公布日期 | 2016.05.10 |
| 申请号 | US201313800094 | 申请日期 | 2013.03.13 |
| 申请人 | GlobeImmune, Inc. | 发明人 | Selitrennikoff Claude P.;Miller Tamara K |
| 分类号 | C12N1/00;A61K39/00 | 主分类号 | C12N1/00 |
| 代理机构 | Sheridan Ross P.C. | 代理人 | Sheridan Ross P.C. |
| 主权项 | 1. A composition comprising: a) non-viable yeast cells Saccharomvces cerevisiae; and b) an antigen from Cryptococcus laccase (Lac) comprising the amino acid sequence of SEQ ID NO:19 or positions 22-624 of SEQ ID NO:19 or chitin deacetylase (CDA) comprising the amino acid sequence of SEQ ID NO:17 or positions 20-249 of SEQ ID NO:19; and wherein the composition is formulated for administration to a subject, and wherein the composition induces a cell-mediated immune response in a subject. | ||
| 地址 | Louisville CO US | ||