| 摘要 |
An ocular iontophoresis device for delivering a medication, comprises a medication reservoir suitable for being positioned on an eye; medication(s) in solution in the reservoir; an active electrode disposed in the reservoir; and a passive electrode. The medication is dissolved in non-saline water. It includes an active principle associated with an additive, e.g. a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome or an emulsion. An ocular iontophoresis device (1) for delivering a medication, comprises a medication reservoir (20) suitable for being positioned on an eye; medication(s) (30) in solution in the reservoir; an active electrode (10) disposed in the reservoir; and a passive electrode (40). The medication is dissolved in non-saline water. The solution has a pH of 6.5-8.5. The medication includes an active principle associated with an additive, e.g. a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion. It has a pKa of 5.5-9.5, and an ionic form of valency of >=1. An independent claim is also included for a method of treatment by ocular iontophoresis, comprising positioning the above iontophoresis device on the eye to deliver medication; and implementing ocular iontophoresis by using the iontophoresis device. |
