| 发明名称 | Methods and compositions for treating bacterial infection | ||
| 摘要 | The present invention relates to methods and compositions for the treatment of bacterial infection, for example extraintestinal E. coli infection such as E. coli bacteremia, meningitis and sepsis. The invention relates also to methods of diagnosis and prevention. | ||
| 申请公布号 | US9333250(B2) | 申请公布日期 | 2016.05.10 |
| 申请号 | US200712226088 | 申请日期 | 2007.04.06 |
| 申请人 | The Johns Hopkins University | 发明人 | Kim Kwang S. |
| 分类号 | A61K39/108;C07K14/245;G01N33/53;A61K39/00 | 主分类号 | A61K39/108 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless Peter F.;Cowles Christopher R. |
| 主权项 | 1. A method for immunizing a subject against a bacterial infection, the method comprising administering to the subject one or more isolated polypeptides or an isolated mRNA or synthetic nucleic acid encoding the one or more polypeptides, wherein the one or more polypeptides are encoded by one or more Escherichia coli (E. coli)-derived island (RDI) sequences selected from the group consisting of RDI 1, RDI 4, RDI 7, RDI 12, RDI 13, RDI 16, RDI 20, RDI 21 and RDI 22,thereby immunizing the subject against the bacterial infection. | ||
| 地址 | Baltimore MD US | ||