Phytoestrogen product of red clover and pharmaceutical uses thereof

摘要

The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating bone remodeling, and prevention and treatment of osteoporosis.

主权项

1. An in vitro method of enhancing osteoblast differentiation, comprising the step of contacting osteoblasts with a composition comprising biochanin A and genistein, wherein the ratio of biochanin A to genistein is 9:1, and the composition comprises a dosage of total phytoestrogens ranging from 1 to 10 mg, wherein the concentration of biochanin A is 9 μM and the concentration of genistein is 1 μM.