Polyvalent polymeric matrix for modified release solid oral preparations and method of preparation thereof

摘要

A polymeric matrix for oral administration with modified release and taste masking properties is disclosed, obtained without using inert supports such as sugar spheres, comprising particles of active substance directly and individually covered with a release regulating membrane. Use of such a matrix to prepare various administration forms for oral use as well as the method of its preparation are also disclosed.

主权项

1. A polymeric matrix for oral administration with modified release, comprising
coated particles of active substance its the form of powder, the particles being directly covered with a release regulating membrane as the coating, wherein inert cores or supports in the particles are eliminated, the particles each have a core composed of only the active substance and omitting all inert substances, the coated particles have a size, together with the coating thereon, between about 790 microns and about 425 microns, the active substance is thioctic acid, and the release regulating membrane comprises shellac and optionally further comprises talc and/or maize starch.