Systems and methods for monitoring health and delivering drugs transdermally

摘要

The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.

主权项

1. A transdermal monitoring and fluid delivery microsystem, comprising:
a substrate including a power source, logic module and at least one connection receptacle; at least one removable transdermal monitoring subsystem mounted to the at least one connection receptacle, the at least one transdermal monitoring subsystem including at least one analyte detector and multiple single-use sampling units, each of the multiple single-use units including:
a microablation heater for ablating a portion of the stratum corneum of a subject's skin in order to access interstitial fluid from the underlying epidermis; anda microchannel for transmitting the accessed interstitial fluid to the at least one analyte detector, wherein the at least one analyte detector communicates detection results to the logic module; and at least one removable microelectromechanical (MEMS) fluid delivery subsystem mounted to the at least one connection receptacle for delivering a fluid to the subject in response to the detection of the analyte by the at least one analyte detector, the MEMS fluid delivery subsystem including means for transdermal fluid delivery to the subject; wherein the logic module provides fluid delivery instructions to the at least one MEMS fluid delivery subsystem in accordance with the detection results from the at least one analyte detector.