Methods and devices for paranasal sinus drug delivery

摘要

Described herein are methods and devices for delivering a drug to the frontal sinus system. An inflatable implant is positioned within the frontal sinus system using an anchoring means secured within the frontal sinus cavity. A drug-containing fluid is released directly into the frontal sinus drainage system.

主权项

1. A method of delivering a fluid to the frontal sinus system of a mammal, the method comprising:
directing an implant into a frontal sinus system of a mammal, the implant including a catheter including a shaft and a core frictionally engaged within a lumen of the shaft, a fluid reservoir secured to a distal portion of the shaft, an anchoring structure secured to a distal tip of the core at a position that is distal to the fluid reservoir, and a dispensing structure, wherein the dispensing structure is in fluid communication with the fluid reservoir and wherein the anchoring structure is configured to move with the core relative to the fluid reservoir and the shaft; positioning the implant so that the anchoring structure is located within a frontal sinus cavity of the frontal sinus system and most or all of the dispensing structure and the fluid reservoir are located within the frontal sinus drainage pathway; applying a force to move the shaft relative to the core so as to adjust the relative position between the fluid reservoir and the anchoring structure; directing a dose of fluid from the fluid reservoir through the dispensing structure, thereby delivering the dose of fluid to the frontal sinus system of the mammal over a period of time of at least a day, at least a portion of the fluid entering the frontal sinus drainage pathway directly from the dispensing structure.