| 发明名称 | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease | ||
| 摘要 | A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammals afflicted therewith, comprising administering to the mammal an effective amount of a non-retinoid antagonist compound or a pharmaceutically acceptable salt thereof. | ||
| 申请公布号 | US9333202(B2) | 申请公布日期 | 2016.05.10 |
| 申请号 | US201314398342 | 申请日期 | 2013.04.30 |
| 申请人 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 发明人 | Petrukhin Konstantin;Sparrow Janet R.;Allikmets Rando |
| 分类号 | A61K31/55;A61K31/497;A61K31/496;A61K31/451;A61K31/4525;A61K31/454;A61K31/4545;A61K31/495;A61K31/506;A61K31/519;A61K31/551 | 主分类号 | A61K31/55 |
| 代理机构 | Cooper & Dunham LLP | 代理人 | White John P.;Cooper & Dunham LLP |
| 主权项 | 1. A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammal afflicted therewith, comprising administering to the mammal an effective amount of a compound having the structure: wherein n=2 or 3; R1 is absent or present and when present, is CH3 or O; α is absent or present, wherein when α present, then R1 is O, and when α is absent, then R1 is CH3; X is Y is N or C; Z isand when n=2, R1 is absent, X is and Y is C, then Z is other than or a pharmaceutically acceptable salt thereof. | ||
| 地址 | New York NY US | ||