发明名称 |
Topical skin care composition |
摘要 |
A cream base for the topical application of skin care therapeutics and a process for making the cream base. In one embodiment, the therapeutic is tretinoin, hydroquinone and fluocinolone acetonide for the treatment of hyperpigmented skin conditions, such as melasma. |
申请公布号 |
US9333172(B2) |
申请公布日期 |
2016.05.10 |
申请号 |
US201414151438 |
申请日期 |
2014.01.09 |
申请人 |
GALDERMA S.A. |
发明人 |
Puglia Nancy;Roth Jerry;Ramirez Rosario |
分类号 |
A61K31/05;A61K31/58;A61K31/203;A61K9/107;A61K8/35;A61K8/63;A61K8/67;A61K9/06;A61Q19/02;A61K8/34;A61K8/69;A61K9/00 |
主分类号 |
A61K31/05 |
代理机构 |
Merchant & Gould, P.C. |
代理人 |
Merchant & Gould, P.C. |
主权项 |
1. A process of making a topical medicated composition, the composition being an emulsion comprising active ingredients consisting of fluocinolone acetonide, hydroquinone and tretinoin, the process comprising the steps of:
(a) preparing an aqueous composition comprising water and at least one hydrophilic compound while heating at a temperature in the range of about 75° C. to about 80° C.; (b) preparing a non-aqueous composition comprising at least two hydrophobic compounds while heating at a temperature in the range of about 75° C. to about 80° C.; (c) combining the aqueous and non-aqueous compositions to form a mixture, wherein steps (a) through (c) are conducted in the absence of an emulsifier; (d) adding at least one emulsifier to the mixture comprising the aqueous and non-aqueous compositions; (e) adding tretinoin to the mixture comprising the aqueous and non-aqueous compositions; (f) adding fluocinolone acetonide to the mixture comprising the aqueous and non-aqueous compositions; (g) adding hydroquinone to the mixture comprising the aqueous and non-aqueous compositions, wherein the hydroquinone is added after adding the at least one emulsifier; and (h) homogenizing the mixture to form the emulsion. |
地址 |
CH |